Do You Really Need 10% Nano Hydroxyapatite in Toothpaste?

While some brands suggest that 10% nano hydroxyapatite is essential for remineralization, this assertion is verifiably false.

This sentiment comes from a misunderstanding of this study in which bovine teeth were soaked in a solution consisting of 0.1% nano hydroxyapatite dissolved in Powerade.

Perhaps obviously, a study conducted by soaking teeth in a sports drink does not correlate with the best concentration of nano hydroxyapatite for remineralization in your toothpaste.


Further, a more recent study conducted by immersing teeth in solutions of varying concentrations of nano hydroxyapatite found that the 5% solution was just as effective at enhancing remineralization and improving tooth hardness as the 10% solution.

Another study even found that 5% nano hydroxyapatite is more effective at remineralization than 10%, likely due to aggregation issues seen at higher concentrations.

As the demand for fluoride-free toothpaste rises, more brands are turning to nano hydroxyapatite toothpaste as a healthier, non-toxic alternative. Still, the question remains: At what concentration is nano hydroxyapatite most effective?

In this article, I’ll explain everything you need to know about nano hydroxyapatite and its efficacy.

What is nano hydroxyapatite?

Nano hydroxyapatite is a derivative of a naturally occurring organic material called calcium phosphate.

Thanks to its function as a biocompatible mineral, nHA has many uses in medicine, including the ability to stimulate bone growth and strengthen enamel.

In fact, one of the most popular uses of nano hydroxyapatite comes from regenerative dentistry in the form of remineralizing toothpaste.

Because it is a natural material, nano hydroxyapatite is safe and effective for people of all ages.

How does nano hydroxyapatite work?

Because it is made from the same materials your teeth are composed of, nano hydroxyapatite toothpaste is shown to prevent tooth decay by filling in your enamel with calcium and phosphate to restore and strengthen your teeth.

The process is simple: a standard diet with acid and sugar will slowly eat away at your enamel. Without intervention, your enamel erodes and cavities form.

Dental professionals use nano hydroxyapatite toothpaste to prevent this erosion, strengthen your teeth, and to improve your oral health overall.

What’s the most effective concentration of nano hydroxyapatite?

NOBS Toothpaste Tablets

The most effective concentration of nano hydroxyapatite is 5%.

For example, one double-blind study found that 5% nano hydroxyapatite toothpaste showed significant anti-caries remineralization effects on enamel.

Another study showed that 5% and 10% nano hydroxyapatite dentifrices were equally effective at remineralizing teeth.

While some studies show the efficacy of 10% nHA toothpaste, one potential issue is the aggregation property of nano hydroxyapatite at higher concentrations which may reduce bioavailability.

Because of this aggregation property, a recent study found that 5% nano hydroxyapatite is more effective at remineralization than 10%.

Further, because nano hydroxyapatite is such an expensive material, it is likely that brands formulating it at a 10% concentration are using the cheapest version: needle-shaped nano hydroxyapatite.

As of 2024, needle-shaped nHA is banned in the European Union due to safety concerns.

In contrast, biöm uses safe 5% rod-shaped nano hydroxyapatite in our toothpaste tablets, and all of our toothpaste is manufactured in FDA-compliant facilities.

Do you really need 10% nHA?

Nano Hydroxyapatite Toothpaste

No, you do not need 10% nano hydroxyapatite in your toothpaste for remineralization benefits.

In fact, the widespread false belief that 10% nano hydroxyapatite toothpaste is the most effective for remineralization came from a misinterpretation of this study in which a 0.1% solution of nano hydroxyapatite in Powerade showed some protective benefits.

Not only did this study not include the use of a 10% nano hydroxyapatite toothpaste, it had nothing to do with 10% nano hydroxyapatite or even toothpaste in general.

As mentioned earlier, many studies show that nano hydroxyapatite is effective at a 5% concentration, and in fact, some studies suggest that 10% nano hydroxyapatite is not as effective as 5% due to aggregation issues.

The Bottom Line: 5% vs. 10% Nano Hydroxyapatite

While some who struggle with scientific literacy suggest that 10% nano hydroxyapatite is essential for remineralization, studies consistently show that the most effective concentration of nano hydroxyapatite is 5%.

At a 5% concentration, nano hydroxyapatite has benefits like soothing hypersensitivity, increasing tooth hardness, and strengthening enamel. Plus, 5% nano hydroxyapatite does not suffer from the same aggregation issues seen at 10% that may decrease bioavailability.

In conclusion, brushing with 5% nano hydroxyapatite toothpaste is a phenomenal way to improve your oral health. Make sure to include it in your routine by brushing for two minutes twice per day alongside regular usage of expandable floss and tongue scraping.

Frequently Asked Questions

What is the best form of hydroxyapatite?
The best form of hydroxyapatite is rod-shaped nano hydroxyapatite. Studies show  that at 5% concentration, this nano hydroxyapatite can remineralize enamel, strengthen teeth, and soothe hypersensitivity.

What percentage of nano hydroxyapatite is in toothpaste?
NOBS Toothpaste Tablets contain 5% nano hydroxyapatite. At this concentration, nano hydroxyapatite can remineralize enamel, strengthen teeth, and soothe hypersensitivity.

Do dentists recommend hydroxyapatite?
Yes, dentists recommend hydroxyapatite. In fact, NOBS Toothpaste Tablets with 5% nano hydroxyapatite were created by a dentist to provide a better alternative for those interested in fluoride-free toothpaste.

Which nano hydroxyapatite toothpaste is best?
NOBS Toothpaste Tablets by biöm is the best nano hydroxyapatite toothpaste. Formulated by a dentist, NOBS were created to provide a non-toxic, zero waste alternative to traditional tube toothpaste for those who prefer to avoid fluoride.

Does nano hydroxyapatite toothpaste really work?
Yes, nano hydroxyapatite toothpaste really does work to soothe hypersensitivity, strengthen teeth, and prevent tooth decay. In fact, studies show that nano hydroxyapatite toothpaste is just as effective as fluoride for protecting teeth.


NOBS Toothpaste Tablets
NOBS Toothpaste Tablets
NOBS Toothpaste Tablets
NOBS Toothpaste Tablets
NOBS Toothpaste Tablets
NOBS Toothpaste Tablets

NOBS Toothpaste Tablets

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NOBS is everything toothpaste should be - all the good stuff, and none of the junk.

Fluoride Free
Never any fluoride, and no harsh abrasives.

We used the magical remineralizing power of nano-hydroxyapatite to protect your teeth long-term. It's the safest alternative to fluoride!

Unlike messy tube toothpaste, NOBS are easy to store and use anywhere.

Thanks to our unique blend of natural ingredients, NOBS will make your breath as fresh as you look. Instead of gross sweeteners that cover up a natural slightly bitter aftertaste, our organic mint will leave you so kissable. Trust us, your date will thank you.

Flex on TSA

NOBS toothpaste tablets don’t apply to the 3.4oz limit. Fly with confidence that you won’t be condemned to a dirty mouth while you travel.

No Mess

Never worry about your toothpaste tube exploding over your other toiletries. NOBS toothpaste tablets come in an air-tight glass jar, free of plastic and without the mess. Unscrew, chew, and renew your mouth.

No Plastic

We want you to disrupt your brushing routine, not your endocrine system. Unlike other brands, our product is free of all plastics and BPAs.

Perfect Size

NOBS toothpaste tablets are individual and perfectly dosed. No more squeezing, no more tube sliding against the edge of your sink and definitely no wasted toothpaste.

Safe for Children

Protecting little ones is our top priority. NOBS provides the safest oral care for pregnant women and their families. Just monitor and ensure that your child can chew and swallow safely before introducing them to NOBS.


This product is not suitable for pets. Humans only, please!

While xylitol is great for supporting the human oral microbiome, it can be toxic to pets. Please keep NOBS away from your furry friends, and contact your veterinarian immediately if consumed by your pet.

Fluoride Free Toothpaste Tablets

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