Is Nano Hydroxyapatite Safe?

Yes, nano hydroxyapatite is safe. While nano particles have previously been scrutinized for safety, evidence suggests that they are safe at up to 10% nano hydroxyapatite concentration in toothpaste.

Not to mention, the inclusion of nano hydroxyapatite particles in toothpaste may offer a better alternative to fluoride, which has been associated with toxicity concerns in some cases.

Nano hydroxyapatite toothpaste has a number of oral care benefits, including:

  • Remineralizing capabilities

  • Strengthening tooth enamel

  • Preventing tooth decay

  • Reducing tooth sensitivity

  • Fighting dry mouth

This article will explain everything you need to know about hydroxyapatite nanoparticles, safety, and benefits.


Nano Hydroxyapatite

Nano hydroxyapatite is a derivative of a naturally occurring organic material called calcium phosphate.

Thanks to its function as a biocompatible mineral, nHA has many uses in medicine, including the ability to stimulate bone growth.

One of the most popular uses comes from regenerative dentistry, in the form of remineralizing toothpaste with nano hydroxyapatite.

When used in toothpaste, nano hydroxyapatite is known for its ability to remineralize teeth and strengthen the tooth surface.


Nano hydroxyapatite

Nano-hydroxyapatite is a derivative of calcium phosphate that is naturally found in your teeth and bones.

While it has many medical applications, some dental professionals promote nano medical hydroxyapatite as an alternative to fluoride in toothpaste.

In fact, it is an effective studied biomaterial that has shown potential for remineralizing and repairing teeth without any undesirable systemic effects.


A lady brushing her teeth

Because it is made from the same materials your teeth are made of, nano hydroxyapatite toothpaste fights tooth decay by filling in your enamel with calcium and phosphate to restore and strengthen your teeth.

A standard diet with acid and sugar will slowly eat away at your enamel. Without intervention, your enamel erodes and cavities form.

Dental professionals use nano hydroxyapatite paste to prevent this erosion and to improve your oral health overall.

Why do people say nano hydroxyapatite isn't safe?

a person with a toothbrush in her mouth

The argument that nano hydroxyapatite isn't safe largely comes from the fear surrounding nano particles. Because nano particles are small, some individuals worry about their potential to penetrate skin or mucous membranes.

However, these concerns only apply to needle-shaped nano hydroxyapatite which is banned by the Scientific Committee on Consumer Safety and cannot legally be used in oral products.

Further, concerns about the safety of nano hydroxyapatite arise from concerns about quality control and changing guidelines from different regulatory bodies.

That's why, here at biöm, we're proud to manufacture our dental products with 5% rod-shaped nano hydroxyapatite in FDA-compliant facilities. In fact, that's what the "NOBS" in our NOBS Toothpaste Tablets stands for - no bad stuff. Get it?

Is nano hydroxyapatite safe for kids?

A kid brushing her teeth

Yes, nano hydroxyapatite is safe for kids. In fact, nano hydroxyapatite is considered by many dentists as a better alternative to fluoride for children for a number of developmental and physical reasons.

For example, some researchers suggest hydroxyapatite is a promising solution early childhood caries. Further, a meta analysis concluded that, "biomimetic hydroxyapatite-containing, fluoride-free oral care products are effective in reducing dental decay, especially in children."

Finally, another study using the International Caries Detection and Assessment System concluded, at the end of a year-long trial, that hydroxyapatite toothpaste was not inferior to a fluoride control toothpaste.

Risks of Fluoride Toothpaste for Children

Nano hydroxyapatite toothpaste for kids is ideal, not only because it strengthens their teeth, but also because it keeps them away from fluoride toothpaste which can have negative side effects.


While you should never be intentionally swallowing your toothpaste, nano hydroxyapatite is safer to ingest for children than fluoride, especially for those living in an area with a high concentration of fluoride in the water supply.

In fact, one study even found that, "Greater exposure to high levels of fluoride in water was significantly associated with reduced levels of intelligence in children."

For this reason, switching to kids hydroxyapatite toothpaste is a good choice to make for your child's safety.

TEETH Discoloration

Excess exposure to fluoride during your child's development can lead to an unsightly condition called dental fluorosis.

When children are exposed to fluoride during tooth development, their dental enamel is disturbed. This leads to lower mineral content and increased porosity throughout their life.

To protect your children, consider switching to a fluoride free toothpaste, like a hydroxyapatite toothpaste, while they're still young.


Similar to tooth development, fluoride also negatively impacts pediatric brain development.

In particular, one study found that "Exposure to increasing levels of fluoride in tap water was associated with diminished non-verbal intellectual abilities".

Nano hydroxyapatite toothpastes, on the other hand, have not been shown to exhibit toxic activity.


A lady with her big smile

Hydroxyapatite nanoparticles are a natural complement to your tooth enamel as they are both made of the same materials.

Thus, nano hydroxyapatite has a number of oral health benefits and makes a great fluoride alternative.


Hydroxyapatite is biocompatible with the human body. It is naturally occurring organic material found in your teeth and bones. Thus, it is safely used in oral care without harmful side effects.


Nano hydroxyapatite is an effective desensitizing agent. Studies show that it is a safe material for reducing dentin hypersensitivity.

By depositing minerals into the protective layer of your teeth, hydroxyapatite toothpaste can reduce tooth sensitivity and make a significant difference in your ability to tolerate temperature, acidity, and sugar.


Hydroxyapatite works by depositing natural minerals back into your teeth through a process called enamel remineralization.

Remineralization is essential for a healthy mouth and protects against tooth loss. This process stimulates bone growth and reduces incidence of cavities.


Nano hydroxyapatite functions to strength your enamel surface and increase the mineral density of your teeth. This process makes your teeth stronger and glossier while also decreasing your chances of tooth decay, leading to a beautiful smile!


Nano hydroxyapatite vs fluoride toothpaste

While fluoride is the historical gold standard in cavity prevention, studies suggest that nano hydroxyapatite is equally as effective as fluoride, if not more, at remineralization.

Interestingly, one study even found that nano hydroxyapatite was more effective than a comparable fluoride varnish.

In this section, we'll explore the differences between the two ingredients.


While fluoride toothpastes work by depositing fluoride ions into your enamel, fluoride free toothpaste with hydroxyapatite works by depositing naturally beneficial materials like calcium and phosphate ions into your enamel.

Since your enamel is already made of calcium and phosphate, among other materials, synthetic hydroxyapatite reinforces the existing tooth structure.


Both fluoride and nano hydroxyapatite toothpaste are effective at supporting good oral health through:

  • reducing teeth sensitivity

  • promoting dentine remineralization

  • preventing tooth decay

  • supporting the oral microbiome

  • and increased enamel surface hardness.

Further, studies show both compounds have similar comparative efficacy for remineralizing teeth, lesion depth reduction, and inhibiting enamel caries progression. 


Since nano hydroxyapatite is a naturally occurring material that your body already makes, there are no safety or toxicity concerns.

On the other hand, fluoride is a controversial ingredient in dentistry for its role in negatively affecting fetal brain development and causing dental fluorosis.


Nano hydroxyapatite is a more expensive ingredient than fluoride. Thus, nano hydroxyapatite toothpastes tend to be more expensive than fluoridated toothpastes.


Fluoride toothpastes are more widely available and can be found at any grocery store, drug store, or online. Hydroxyapatite toothpaste brands are less widely available and more likely to be found online than in retail stores.


Yes, nano hydroxyapatite toothpaste is safer than conventional fluoride toothpaste.

Research suggests that nano hydroxyapatite toothpaste may have fewer safety concerns compared to fluoride toothpaste, particularly for certain populations such as:

  • Pregnant women

  • People prone to tooth decay and cavities

  • People who live in environments with high fluoride concentrations in the water

So, do yourself a favor and pick up some nano hydroxyapatite toothpaste tablets today.

But does it reverse cavities?

While studies suggest that nano hydroxyapatite can decrease the depth of initial enamel caries, but we do not have enough evidence to conclude that nano hydroxyapatite reverses cavities at this time.

However, research shows that nano hydroxyapatite is excellent at remineralizing teeth. Remineralization is the first step to preventing tooth decay and, ultimately, cavities.

In fact, one study even showed that nano hydroxyapatite was capable of remineralizing teeth better than a fluoride varnish.

Is nano hydroxyapatite good for tooth sensitivity?

Yes, nano hydroxyapatite is good for treating tooth sensitivity.

One study even found that nano hydroxyapatite toothpaste significantly reduces dentin hypersensitivity in less than two weeks. Another study showed that nano hydroxyapatite toothpaste was effective at relieving sensitivity when used twice daily.

Still further, another paper suggests nano hydroxyapatite "can be advocated in the management of hypersensitivity".


No, nano hydroxyapatite is not banned in the EU.

As of March 2023, the EU Scientific Committee of Consumer Safety determined "hydroxyapatite (nano) safe when used at concentrations up to 10% in toothpaste, and up to 0.465% in mouthwash".

This conclusion came after much research and debate over the safety and potential health risks of nano sized particles in oral cosmetics.


Nano hydroxyapatite is generally regarded as safe by the FDA, but it has not yet been fully approved as a medical device for regenerative dentistry practices.

In layman's terms, nano hydroxyapatite has been studied for its safety as an ingredient, but there are marketing restrictions around it at this time.

Can you swallow nano hydroxyapatite?

A man gargling

Yes, you can swallow nano hydroxyapatite safely. In fact, research suggests that your stomach acid immediately dissolves nano hydroxyapatite particles if you swallow them.

That's why nano hydroxyapatite toothpaste is the best choice for children who haven't quite learned how to brush their teeth properly yet!

Does nano hydroxyapatite toothpaste "feel" different?

No, nano hydroxyapatite toothpaste doesn't feel any different than your traditional fluoride toothpaste.

While our nano hydroxyapatite toothpaste tablets come in a chewable form that dissolves into a foamy paste, our kids hydroxyapatite toothpaste toothpaste feels like your standard tube toothpaste.

No grittiness or unpleasant flavor - just pure safety and efficacy!

The Bottom Line: Is nano hydroxyapatite safe to use?

A lady holding NOBS Toothpaste

The answer is straightforward yes, nano hydroxyapatite is safe to use. In fact, research indicates that nano hydroxyapatite toothpaste may have fewer safety concerns compared to fluoride toothpaste.

Nano hydroxyapatite particles do not induce toxicity the way overconsumption of fluoride can. This is particularly important for certain populations such as:

  • pregnant women

  • children

  • people prone to tooth decay and cavities

  • people who live in environments with high fluoride concentrations in the water

Therefore, choosing nano hydroxyapatite toothpaste tablets can be your ideal step toward a safer and more effective oral care routine.


How does nano hydroxyapatite feel on your teeth?
Nano hydroxyapatite leaves your teeth feeling smooth and glossy. It's an effective remineralizing agent that naturally fills the holes in your enamel and prevents cavities.

Is Nano hydroxyapatite FDA approved?
Nano hydroxyapatite is regarded as generally safe by the FDA, but it is not approved as a medical device for the specific treatment of cavities. There is sufficient evidence of nano hydroxyapatite safety and its ability to effectively treat a number of oral health conditions.

Do dentists recommend hydroxyapatite?
Yes, dentists recommend nano hydroxyapatite toothpaste for daily use. Unlike fluoride, nano hydroxyapatite toothpaste has a number of dental benefits with no toxicity concerns.

Where does nano hydroxyapatite come from?
Nano hydroxyapatite is derived from calcium phosphate, a substance naturally present in your teeth and bones. It has various medical applications, and in dentistry, it is used for its remineralizing properties.

How does nano hydroxyapatite work?
Nano HA toothpaste works by depositing minerals back into your teeth. This oral care mechanism supports your tooth enamel and prevents tooth decay through a process called remineralization. It mimics the natural composition of your teeth to help combat the erosion caused by a diet high in acid and sugar, promoting overall oral health.

Is nano hydroxyapatite harmful to your teeth?
No, nano hydroxyapatite is not harmful to your teeth. Numerous studies have investigated the safety of nano-hydroxyapatite, with key findings supporting its safety in dental applications. A study from 2022, which assessed the effectiveness of hydroxyapatite toothpastes like n-Ha against dental caries, reported no adverse effects associated with the chemical.

Can I use nano hydroxyapatite toothpaste everyday?
Yes, you can use nano hydroxyapatite toothpaste every day. It's just as effective as fluoride but safer since it's made from natural minerals. Using it daily makes your teeth stronger, safeguards enamel, and prevents decay, keeping your oral health in great shape.

NOBS Toothpaste Tablets
NOBS Toothpaste Tablets
NOBS Toothpaste Tablets
NOBS Toothpaste Tablets
NOBS Toothpaste Tablets
NOBS Toothpaste Tablets
NOBS Toothpaste Tablets
NOBS Toothpaste Tablets
NOBS Toothpaste Tablets

NOBS Toothpaste Tablets

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NOBS is everything toothpaste should be - all the good stuff, and none of the junk.

Fluoride Free
Never any fluoride, and no harsh abrasives.

We used the magical remineralizing power of 5% nano-hydroxyapatite to protect your teeth long-term. It's the safest alternative to fluoride!

Unlike messy tube toothpaste, NOBS are easy to store and use anywhere.

Thanks to our unique blend of natural ingredients, NOBS will make your breath as fresh as you look. Instead of gross sweeteners that cover up a natural slightly bitter aftertaste, our organic mint will leave you so kissable. Trust us, your date will thank you.

Cleans Effectively Without Damaging Enamel

With an enviable RDA of 21.38, NOBS Toothpaste Tablets are intentionally designed to help you gently buff out surface stains and break up plaque biofilm without causing damage to your enamel. Thanks, baking soda!

Flex on TSA

NOBS toothpaste tablets don’t apply to the 3.4oz limit. Fly with confidence that you won’t be condemned to a dirty mouth while you travel.

No Mess

Never worry about your toothpaste tube exploding over your other toiletries. NOBS toothpaste tablets come in an air-tight glass jar, free of plastic and without the mess. Unscrew, chew, and renew your mouth.

No Plastic

We want you to disrupt your brushing routine, not your endocrine system. Unlike other brands, our product is free of all plastics and BPAs.

Perfect Size

NOBS toothpaste tablets are individual and perfectly dosed. No more squeezing, no more tube sliding against the edge of your sink and definitely no wasted toothpaste.

Safe for Children

Protecting little ones is our top priority. NOBS provides the safest oral care for pregnant women and their families. Just monitor and ensure that your child can chew and swallow safely before introducing them to NOBS.

This product is not suitable for pets. Humans only, please!

While xylitol is great for supporting the human oral microbiome, it can be toxic to pets. Please keep NOBS away from your furry friends, and contact your veterinarian immediately if consumed by your pet.

Fluoride Free Toothpaste Tablets